The onset of genocide of the natives of American continent and mass enslavement of Africans.
"Between 1500 and 1866, Europeans transported to the Americas nearly 12.5 million enslaved Africans, about 1.8 million of whom died on the Middle Passage, their bodies thrown into the Atlantic."
Destruction of cultures, looting and spread of false religions.
Columbus returned home to Spain and came back to the Caribbean with 17 ships and 1,200 men. His men traveled from island to island, taking Indians as captives. In 1495, in a large slave raid, Columbus and his men rounded up 1,500 Arawak men, women, and children, and put them in pens. They selected what they considered the best natives and loaded them onto ships back to Spain. Two hundred died en route. After the survivors were sold as slaves in Spain, Columbus later wrote: "Let us in the name of the Holy Trinity go on sending all the slaves that can be sold